This study examines the formulation and evaluation of floating tablets containing azelastine hydrochloride intended to treat gastroretention. Gastroretentive drug delivery systems increase absorption and bioavailability while reducing the frequency of administration. Considering its short biological half-life and the need for sustained release formulations, azelastine, a potent antihistamine with potential anti-inflammatory properties, was chosen as the model drug. As a means of achieving buoyancy and controlling drug release, polymers were used in the preparation of the tablets. A central composite design (CCD) was used to study the effects of polymer concentration and gas-forming agent (sodium bicarbonate) on tablet properties such as floating lag time, total floating time, and drug release. A number of parameters, including weight variation, hardness, friability, and in vitro drug release, were measured on the tablets. The developed azelastine floating tablets showed promising gastroretentive properties and sustained drug release

Chemical hazards pose significant risks in pharmaceutical industries and laboratories. This topic examines the types, sources, routes of exposure, and effects of chemical hazards commonly encountered in these settings. Major categories discussed include irritants, sensitizers, carcinogens, corrosives, mutagens, teratogens, reactive chemicals, and flammables. Common hazardous chemicals like methanol, ethylene glycol, and heavy metals are explored in detail, along with their toxicities and treatment approaches. This topic outlines key preventive measures, including engineering controls, administrative practices, and personal protective equipment. Proper handling, storage, labeling, and disposal procedures are emphasized. A systematic approach to hazard identification, risk assessment, and implementation of control measures is recommended to minimize chemical exposures and protect worker health and safety. This content provides practical guidelines for managing chemical hazards through a combination of technical, organizational, and personal protective strategies in pharmaceutical and laboratory environments

In the present work the approach of forced degradation study was successfully applied for the development of stability-indicating assay method for determination of Prasugrel Hydrochloride in the presence of its degradation products. The RP-HPLC separation was carried out on Agilent HPLC 1200 series, Waters HPLC with Empower software waters 2996 PDA, 2487, waters 2695 separation module PDA were used for quantitative estimation of PRA in pharmaceutical dosage form using a Hypersil BDS, 5? (150×4.6mm) with mobile phase comprising Buffer: Acetonitrile (60:40) at flow rate of 1.0mL/min and UV detection at 210.0 nm. The method was validated as per ICH guidelines for accuracy, precision, specificity, linearity and range, ruggedness and robustness. The linearity of the proposed method was investigated in the range of 80-120% of label claim; the correlation coefficient for Prasugrel Hydrochloride was found to be 0.9998. The proposed method was found to be simple, specific, linear and rugged and can be used for routine quality control.

Two novel series of s-triazine derivatives (6a–e and 7a–f) were synthesized with various aromatic and heterocyclic amines. The synthesized compounds were subsequently evaluated for their in vitro antibacterial activity against three gram-positive viz. Bacillus subtilis (NCIM-2063), Bacillus cereus (NCIM-2156), Staphylococcus aureus (NCIM-2079) and gram-negative bacteria viz. Pseudomonas aeruginosa (NCIM-2036), Escherichia coli (NCIM-2065) and Klebseilla pneumoniae (NCIM-2706) by the broth dilution method as recommended by the National Committee for Clinical Laboratory Standards (NCCLS) using streptomycin as reference standard. Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data.

Mechanical hazards in the pharmaceutical industry represent a significant risk to worker safety and operational efficiency. This journal article presents a detailed study on the types, impacts, and mitigation strategies associated with mechanical hazards in pharmaceutical manufacturing environments. The research identifies common mechanical dangers, such as moving components, mechanical failures, and ergonomic concerns, using data from current industry publications, safety studies, and incident case studies. The study reveals that moving parts, such as rotating shafts and conveyor belts, are common sources of entanglement and injury. Mechanical failures, such as gear malfunctions and hydraulic leaks, often lead to unpredictable machine behavior and operational disruptions. Mitigation strategies are examined, focusing on equipment design improvements, regular maintenance schedules, and enhanced safety training programs. The study highlights the effectiveness of incorporating safety guards, emergency stop mechanisms, and rigorous lockout/tagout procedures. In addition, it highlights that following legal requirement like OSHA guidelines is essential to lowering the risk of mechanical risks. The results emphasize the necessity of a proactive safety management strategy in the production of pharmaceuticals. Precautions that should be taken include putting modern safety technologies into practice, encouraging a safety-conscious culture, and regularly upgrading safety protocols to handle changing hazards. This study offers insightful information that can help the pharmaceutical sector improve operational dependability and worker safety