About IJPDT
1. | FORMULATION AND EVALUATION OF ACECLOFENAC EFFERVESCENT TABLETS | |||||
Kamireddy Jammeswaramma*, Umasankar K, Jayachandra Reddy P | ||||||
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Aceclofenac is a NSAID which has greater inhibitory action against the inducible from of cyclooxygenase (cox-2) which is implicated in the inflammatory response against the constitutive form of this enzyme (cox-1) inhibition. The aim of this study was to formulate Effervescent tablet by wet granulation with sufficient mechanical integrity and to achieve faster disintegration in the water. Effervescent tablet are uncoated tablets that generally contain acid substances and carbonates or bicarbonates and which react rapidly in the presence of water by releasing carbon dioxide. They are intended to be dissolved or dispersed in water before use. Effervescent compositions in the form of tablets comprising a therapeutic agent, a granulating agent, a micro particulate effervescent component and an effervescent system which dissolve rapidly in water to yield an effervescent solution containing a completely dissolved therapeutic agent and a process for their preparation. Keywords: Aceclofenac, NSAID, Formulation. |
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