Azithromycin is an oral antibiotic used for the treatment of bactrerial infections. It belongs to the It is an azalide, a subclass of macrolide antibiotic. It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered. Azithromycin is somewhat more potent against certain bacterial species than erythromycin, but its widespread popularity arises primarily from its slow elimination from the body, which allows many infections to be treated with 3–5 days of once-daily administration, compared to 3-4 times a day for up to two weeks for erythromycin. The conventional dosage form such as tablets and capsules are the major oral preparations. Conventional dosage form have wide acceptance up to 50-60% of total dosage forms. Solid dosage forms are popular because of ease of administration, accurate dosage, self-medication, pain avoidance and most importantly the patient compliance in last two decades the drug delivery technology has been developed rapidly and many novel oral drug delivery systems have been invented. Keywords: Azithromycin, Matrix Tablets, Sustained Release.