Pravastatin is a cholesterol-lowering agent that belongs to a class of medications known as statins. The present work is to
develop and evaluation of press coated tablets of pravastatin by using polymers like Ethyl cellulose, carbopol. From the
reproducible results obtained from the executed trails of core and press coated tablets it can be concluded that F3 of core tablet
and F10 of coated tablet were maintained lag phase upto 6hrs and brust release was at 7th hr and followed by maximum release at
the end of 8th hr, so it is selected as optimized formulations for designing Pulsatile device. Therefore the study proved that
coated Pravastatin can be successfully used as a time dependent modified Chronopharmaceutical formulation.

Ultra violet ray absorption is reduced by applying sunscreen reaches the skin and also reduces sun induced diseases such
as skin cancer, erythema. The present study is to develop sunscreen as anti UV radiation activity. Phytoconstituents like phenolic
acid, polyphenols and flavanoids are used for the protection of the skin from internal and external harming agents and these are
mostly used in cosmetic purpose. The ingredients which are extracted from the plants are used on the skin to perform healing of
the skin, smoothness, restore the damage. The recent study was involved in preparing the herbal sunscreen lotions with bioactive
components like Crocus sativus, aloe vera, and solanum tuberosum extracts are evaluated with diffuse transmitant extract and
should monitor SPF. The formulations with herbal extracts (ACA and ACB) showed comparatively high SPF on the formulation
devoid of these extracts (ACC) and stood competitive to the standard marketed formulations.

Addition of adjuvants to local anaesthetic in supraclavicular brachial plexus Block helps in improving duration of block and analgesia. We compare clonidine and Dexmedetomidine in supraclavicular brachial plexus block. Method: A total of 80 patients aged from 20 to 55 years belonging to ASA I-II scheduled for Upper limb surgery were included and divided into three groups- Group I received 0.5%, normal saline, Group II received 0.5% clonidine and Group III dexmedetomidine. The patients were compared for onset as well as duration of sensory and motor blockade, duration of analgesia and haemodynamic Side effects. Results: The mean duration of sensory and motor block as well as analgesia was found to be More (statistically highly significant p<0.001) in group III (dexmedetomidine group) having A much longer duration of sensory and motor block as well as analgesia compared to group I and group II (clonidine group). Conclusion: Therefore, in present study it was found that addition of clonidine and Dexmedetomidine are effective in supraclavicular brachial plexus block. However, dexmedetomidine is a better alternative to clonidine as adjuvant to obtain early onset and prolong the duration of sensory and motor block and Postoperative analgesia

Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of fluid administration as drug diluent or to preserve catheter patency should also be considered. As for antibiotics, intravenous fluid administration should follow the four Ds: drug, dosing, duration, de-escalation. Among crystalloids, balanced solutions limit acid–base alterations and chloride load and should be preferred, as this likely prevents renal dysfunction. Among colloids, albumin, the only available natural colloid, may have beneficial effects. The last decade has seen growing interest in the potential harms related to fluid overloading. In the fluid management that maintains adequate organ perfusion while limiting fluid administration should represent the standard of care. Protocols including a restrictive continuous fluid administration alongside bolus administration to achieve hemodynamic targets have been administered